Tree Gibbs Sampler is a software for identifying motifs by simultaneously using the motif overrepresentation property and the motif evolutionary conservation property. It identifies motifs without depending on pre-aligned orthologous sequences, which makes it useful for the extraction of regulatory elements in multiple genomes of both closely related and distant species.
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Bioinformatics. 2007 Aug 1;23(15):2013-4. Epub 2007 May 31.
Tree Gibbs Sampler: identifying conserved motifs without aligning orthologous sequences.
Cai X, Hu H, Li XS.