CCSOL / ccSol omics – Prediction of Protein Solubility

CCSOL / ccSol omics

:: DESCRIPTION

CCSOL is a predictor of protein solubility based on the physicochemical properties of amino acid sequences.

ccSol omics is a method to perform large-scale solubility predictions of endogenous and heterologous protein expression in E. coli

::DEVELOPER

Tartaglia Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

ccSOL omics: a webserver for large-scale prediction of endogenous and heterologous solubility in E. coli.
Agostini F, Cirillo D, Livi CM, Delli Ponti R, Tartaglia GG.
Bioinformatics. 2014 Jul 1. pii: btu420.

J Mol Biol. 2012 Aug 10;421(2-3):237-41. doi: 10.1016/j.jmb.2011.12.005. Epub 2011 Dec 9.
Sequence-based prediction of protein solubility.
Agostini F1, Vendruscolo M, Tartaglia GG.

SCM 1.0 – Prediction and Analysis of Protein Solubility

SCM 1.0

:: DESCRIPTION

SCM is a novel scoring card method by using dipeptide composition only to estimate solubility scores of sequences for predicting protein solubility.

::DEVELOPER

Intelligent Computing Lab. 

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux
  • Python

:: DOWNLOAD

 SCM

:: MORE INFORMATION

Citation

BMC Bioinformatics. 2012;13 Suppl 17:S3. doi: 10.1186/1471-2105-13-S17-S3. Epub 2012 Dec 13.
Prediction and analysis of protein solubility using a novel scoring card method with dipeptide composition.
Huang HL1, Charoenkwan P, Kao TF, Lee HC, Chang FL, Huang WL, Ho SJ, Shu LS, Chen WL, Ho SY.

SOLpro – Prediction of Protein Solubility upon Overexpression

SOLpro

:: DESCRIPTION

SOLpro predicts the propensity of a protein to be soluble upon overexpression in E. coli using a two-stage SVM architecture based on multiple representations of the primary sequence. Each classifier of the first layer takes as input a distinct set of features describing the sequence. A final SVM classifier summarizes the resulting predictions and predicts if the protein is soluble or not as well as the corresponding probability.

::DEVELOPER

Institute for Genomics and Bioinformatics

:: SCREENSHOTS

N/A

:: REQUIREMENTS

:: DOWNLOAD

 SOLpro

:: MORE INFORMATION

Citation:

Magnan CN, Randall A, Baldi P.
SOLpro: accurate sequence-based prediction of protein solubility.
Bioinformatics. 2009 Sep 1;25(17):2200-7. Epub 2009 Jun 23.