JMassBalance is a tool for mass-balanced randomization and analysis of metabolic networks. The tool allows efficient generation of large sets of randomized networks under the physical constraint of mass balance. In addition, various structural properties of the original and randomized networks can be calculated, facilitating the identification of the salient properties of metabolic networks with a biologically meaningful null model.
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Georg Basler and Zoran Nikoloski (2011):
JMassBalance: mass-balanced randomization and analysis of metabolic networks.
Bioinformatics, 27(19):2761-2762. doi:10.1093/bioinformatics/btr448