GEMS is a suit of softweares for entropy-scaling searching of massive biological data.
Ammolite is production-quality software designed to do a Tanimoto distance similarity search over chemical graphs for small molecules.
MICA (Metagenomic Inquiry Compressive Acceleration) is a full drop-in replacement for BLASTX and DIAMOND supporting all command-line options that is 3.5x faster than DIAMOND (and over 3000x faster than BLASTX) with no loss in specificity and less than 5% loss in sensitivity.
esFragBag (entropy-scaling FragBag) is prototype software that applies entropy-scaling to accelerate only the all r-nearest neighbor search functionality of FragBag by a factor of ~10 with no loss in specificity and less than 0.2% loss in sensitivity.
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Entropy-scaling search of massive biological data.
Yu YW, Daniels NM, Danko DC, Berger B.
Cell Syst. 2015 Aug 26;1(2):130-140.