EI_EXCHANGE ( External and Internal Exchange) is a program to calculate elementary modes for the complete variety of external and internal metabolites and a program to calculate the approximated minimal number of mode.
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T. Dandekar, F. Moldenhauer, S. Bulik, H. Bertram, S. Schuster:
A method for classifying metabolites in topological pathway analyses based on minimization of pathway number.
BioSystems, 2003, 70, 255-270