BIOSAP (Blast Integrated Oligonucleotide Selection Accelerator Package) generate oligos for the Inkjet Arrayer. BIOSAP provides the opportunity to design thousands of oligonucleotides to a given set of biological DNA sequences. The features (oligos) reported are guaranteed to be unique among all features chosen, have certain properties based on the requirements specified by the user, are checked for potential self-hybridizing properties, and are BLAST (Altschul et al., 1990) searched for possible close alignments to genomic sequences other than one for which the given feature was chosen. The final output of BIOSAP is an XML document containing the details and results of the search. This data can be imported into a database to be searched for future iterations of microarray design.
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