bgmm is an R package for knowledge-based mixture modeling. It implements mixture modeling variants, which differ with respect to the amount of incorporated knowledge, and spread the entire range from unsupervised to supervised modeling.
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Introducing knowledge into differential expression analysis.
Szczurek E, Biecek P, Tiuryn J, Vingron M.
J Comput Biol. 2010 Aug;17(8):953-67. doi: 10.1089/cmb.2010.0034.