3V (Voss Volume Voxelator) is collection of program for the assessment of volumes in protein files.. These tools include methods for displaying the surface of macromolecules and extracting internal channels.
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Neil R. Voss and Mark Gerstein
3V: cavity, channel and cleft volume calculator and extractor‘
Nucleic Acids Res. 2010 July 1; 38(Web Server issue): W555–W562.