WAFFECT (pronounced ‘double-u affect’ for ‘weighted affectation’) is a package to simulate phenotypic (case or control) datasets under a disease model H1 such that the total number of cases is constant across all the simulations (the constrain in the title).
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Hum Hered. 2012;73(2):95-104. doi: 10.1159/000336194. Epub 2012 Mar 28.
Alternative methods for H1 simulations in genome-wide association studies.
Perduca V, Sinoquet C, Mourad R, Nuel G.