UbPred – Determine whether a Lysine Residue in a protein is ubiquitinate



UbPred is a software package and web tool that probabilistically determines whether a lysine residue in a protein is ubiquitinated.UbPred is a random forest-based predictor of potential ubiquitination sites in proteins. It was trained on a combined set of 266 non-redundant experimentally verified ubiquitination sites available from our experiments and from two large-scale proteomics studies (Hitchcock, et al., 2003; Peng, et al., 2003). Class-balanced accuracy of UbPred reached 72%, whereas the AUC (area under the ROC curve) was estimated to be ~80%.



Predrag Radivojac (Indiana University, School of Informatics), Vladimir Vacic (Columbia University) and Lilia Iakoucheva (The Rockefeller University, Laboratory for Statistical Genetics).


  • Linux / Windows





Radivojac, P., Vacic, V., Haynes, C., Cocklin, R. R., Mohan, A., Heyen, J. W., Goebl, M. G., and Iakoucheva, L. M.
Identification, Analysis and Prediction of Protein Ubiquitination Sites.
Proteins: Structure, Function, and Bioinformatics. 78(2):365-380. (2010)

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