trueFS is a program used for finding the ascertainment corrected frequency spectrum based on ascertained SNP data. It can perform the corrections under multiple different models including double-hit ascertainment models and ascertainment with or without overlap between the original ascertainment sample and the final genotyped sample. It uses a bootstrap method to quantify statistical uncertainty in the estimates
- Windows / Linux
- C Compiler
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Nielsen, R., M. J. Hubisz and A. G. Clark. 2004.
Reconstituting the frequency spectrum of ascertained SNP data.
Genetics 168: 2373-2382.