The TRIMM (TRIad Multi-Marker) program performs max_Z2, and sum_log(P) tests, association tests for a child’s or mother’s genetic effects using multiple markers from triad families. Statistical significance is evaluated via permutation. It also outputs the nominated risk-haplotype-tagging alleles
- R package
:: MORE INFORMATION
Shi M, Umbach DM ,Weinberg CR
“Identification of Risk-related Haplotypes Using Multiple SNPs from Nuclear Families“.
The American Journal of Human Genetics, Volume 81, Issue 1, 53-66, 1 July 2007