tmax is a program for performing association analysis on a set of linked loci within a targeted region. It has 2 optional approaches, TMAX and SMAX, which are based on single locus test statistics (the log odds ratio) computed for each measured locus. TMAX utilizes the maximum of this series of test statistics, correcting for multiple testing by permutation of case-control status. SMAX utilizes the maximum of a smoothed curve fitted to the series of of test statistics. Again, the p-value is determined by permutation of case-control status.
- Linux / Windows
- R Package
:: MORE INFORMATION
Roeder, Bacanu, Sonpar, Zhang, and Devlin.
“Analysis of Single-Locus Tests to Detect Gene/Disease Associations”
Genet Epidemiol. 2005 Apr;28(3):207-19.