The Tlinkage programs described here are an extension of the general LINKAGE programs for genetic linkage analysis. The extension consists of allowing for a disease phenotype to be under the control of two loci. The current version (20 Apr 2007) corrected a bug that had an effect only with relatively large numbers of alleles at the marker loci.
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Schork NJ, Boehnke M, Terwilliger JD, Ott J (1993)
Two trait locus linkage analysis: a powerful strategy for mapping complex genetic traits.
Am J Hum Genet 53, 1127-1136