TF-Cluster can be used to identify a set of transcription factors (TFs) controlling a biological process of interest from gene expression data. Its high accuracy in recognizing true positive TFs involved in a biological process makes it extremely valuable in building core GRNs controlling a biological process.
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BMC Syst Biol. 2011 Apr 15;5:53. doi: 10.1186/1752-0509-5-53.
TF-Cluster: a pipeline for identifying functionally coordinated transcription factors via network decomposition of the shared coexpression connectivity matrix (SCCM).
Nie J, Stewart R, Zhang H, Thomson JA, Ruan F, Cui X, Wei H.