Tango is a computer algorithm for prediction of aggregating regions in unfolded polypeptide chains.The model used by the TANGO algorithm is designed to predict cross-beta aggregation in peptides and denatured proteins and consists of a phase-space encompassing the random coil and 4 possible structural states: beta-turn, alpha-helix, beta-sheet aggregation and alpha-helical aggregation.
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Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins.
Fernandez-Escamilla AM, Rousseau F, Schymkowitz J, Serrano L.
Nat Biotechnol. 2004 Oct;22(10):1302-6