TakeABreak is a tool that can detect inversion breakpoints directly from raw NGS reads, without the need of any reference genome and without de novo assembling the genomes. Its implementation has a very limited memory impact allowing its usage on common desktop computers and acceptable runtime.
- C++ Compiler
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Claire Lemaitre, Liviu Ciortuz and Pierre Peterlongo,
Mapping-free and assembly-free discovery of inversion breakpoints from raw NGS reads
Proceedings of AlCoB 2014, in Algorithms for Computational Biology, LNCS vol. 8542, pp. 119–130.