TMHcon is a software to predict helix-helix contacts specifically within the transmembrane parts of membrane proteins. It includes predictions by two different neural networks, one developed for helix-helix contacts on all transmembrane helix pairs and one specifically tailored for the prediction of helix-helix contacts lying on non-neighboring transmembrane helices.
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Proteins. 2009 Mar;74(4):857-71. doi: 10.1002/prot.22194.
Prediction of helix-helix contacts and interacting helices in polytopic membrane proteins using neural networks.
Fuchs A1, Kirschner A, Frishman D.