Ortholuge is a computational method that can generate precise ortholog predictions between two species on a genome-wide scale (using additional outgroup data for reference). It can either evaluate a previously constructed set of orthologs or it can generate an initial tentative set of orthologs that are subsequently evaluated. Precise ortholog prediction is important for a variety of analyses that utilize comparative genomics, including regulatory element identification.
Brinkman Laboratory, Simon Fraser University
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Fulton DL, Li YY, Laird M, Horsman BGS, Roche FMR, Brinkman FSL.
Improving the specificity of high-throughput ortholog prediction.
BMC Bioinformatics, 2006. 7:270.