A statistical framework leveraging data obtained from both single cell and bulk sequencing strategies. The ddClone is predicated on the notion that single cell sequencing data will inform and improve clustering of allele fractions derived from bulk sequencing data in a joint statistical model.
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Genome Biol. 2017 Mar 1;18(1):44. doi: 10.1186/s13059-017-1169-3.
ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data.
Salehi S, Steif A, Roth A, Aparicio S, Bouchard-Côté A, Shah SP