minimac 2 2014.9.15 – Faster Genotype Imputation

minimac 2 2014.9.15

:: DESCRIPTION

minimac is designed to work on phased genotypes and can handle very large reference panels with hundreds or thousands of haplotypes.

::DEVELOPER

Abecasis Group

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 minimac2

:: MORE INFORMATION

Citation:

minimac2: faster genotype imputation.
Fuchsberger C, Abecasis GR, Hinds DA.
Bioinformatics. 2014 Oct 22. pii: btu704.

Gigwa 2.2 – Genotype Investigator for Genome Wide Analyse

Gigwa 2.2

:: DESCRIPTION

The Gigwa application provides an easy and intuitive way to explore large amounts of genotyping data by filtering it not only on the basis of variant features, including functional annotations, but also matching genotype patterns. It is a fairly lightweight, web-based, platform-independent solution that may be deployed on a workstation or as a data portal. It allows to feed a MongoDB database with VCF, PLINK or HapMap files containing up to tens of billions of genotypes, and provides a user-friendly interface to filter data in real time.

:: DEVELOPER

The Computational Biology Institute (IBC)

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web Browser

:: DOWNLOAD

Gigwa

:: MORE INFORMATION

Citation

Gigwa v2-Extended and improved genotype investigator.
Sempéré G, Pétel A, Rouard M, Frouin J, Hueber Y, De Bellis F, Larmande P.
Gigascience. 2019 May 1;8(5). pii: giz051. doi: 10.1093/gigascience/giz051.

Gigwa-Genotype investigator for genome-wide analyses.
Sempéré G, Philippe F, Dereeper A, Ruiz M, Sarah G, Larmande P.
Gigascience. 2016 Jun 6;5:25. doi: 10.1186/s13742-016-0131-8.

PlasmidTron 0.4.1 – Assembling the cause of Phenotypes and Genotypes from NGS data

PlasmidTron 0.4.1

:: DESCRIPTION

PlasmidTron utilizes the phenotypic data normally available in bacterial population studies, such as antibiograms, virulence factors, or geographical information, to identify traits that are likely to be present on DNA that can randomly reassort across defined bacterial populations. It is also possible to use this methodology to associate unknown genes/sequences (e.g. plasmid backbones) with a specific molecular signature or marker (e.g. resistance gene presence or absence) using PlasmidTron. PlasmidTron uses a k-mer-based approach to identify reads associated with a phylogenetically unlinked phenotype.

::DEVELOPER

Pathogen Informatics, Wellcome Trust Sanger Institute

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

PlasmidTron

:: MORE INFORMATION

Citation

PlasmidTron: assembling the cause of phenotypes and genotypes from NGS data,
Andrew J Page, Alexander Wailan, Yan Shao, Kim Judge, Gordon Dougan, Elizabeth J. Klemm, Nicholas R. Thomson, Jacqueline A. Keane, 2018,
Microbial Genomics 4(3); doi: 10.1099/mgen.0.000164

fastStructure 1.0 – Inferring Population Structure from SNP Genotype data

fastStructure 1.0

:: DESCRIPTION

fastStructure is an algorithm for inferring population structure from large SNP genotype data.

::DEVELOPER

Pritchard Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows / Linux / Mac OsX
  • Python
  • Numpy
  • Scipy
  • Cython
  • GNU Scientific Library

:: DOWNLOAD

 fastStructure

:: MORE INFORMATION

Citation

fastSTRUCTURE: variational inference of population structure in large SNP data sets.
Raj A, Stephens M, Pritchard JK.
Genetics. 2014 Jun;197(2):573-89. doi: 10.1534/genetics.114.164350

sampletrees 20151127 / Rsampletrees 1.0.2 – Sampling Gene Genealogies Conditional on SNP Genotype data

sampletrees 20151127 / Rsampletrees 1.0.2

:: DESCRIPTION

The program sampletrees is a Markov chain Monte Carlo sampler of gene genealogies conditional on either phased or unphased SNP genotype data. The companion program Rsampletrees is for pre- and post-processing of sampletrees files, including setting up the files for sampletrees and storing and plotting the output of a sampletrees run.

::DEVELOPER

SFU Statistical Genetics working group

:: REQUIREMENTS

:: DOWNLOAD

 sampletrees / Rsampletrees 

:: MORE INFORMATION

Citation

sampletrees and Rsampletrees: Sampling gene genealogies conditional on SNP genotype data.
Burkett KM, McNeney B, Graham J.
Bioinformatics. 2016 Jan 18. pii: btv763.

IGG 3.0 – Integrate Genotypes for genome-wide Genetic studies

IGG 3.0

:: DESCRIPTION

IGG (Integrate Genotypes for genome-wide Genetic studies) is an open-source Java package with graphic interface to efficiently and consistently integrate genotypes across high throughput genotyping platforms (e.g., Affymetrix and Illumina), the HapMap genotype repository (http://www.hapmap.org/), and even genotypes from the collaborators’ projects. It is equipped with a series of functions to control qualities of genotype integration and to flexibly export genotypes for genetic studies as well.

::DEVELOPER

Miao-xin Li ,The University of Hong Kong

:: SCREENSHOTS

:: REQUIREMENTS

  • Windows / Linux / MacOSX
  • Java

:: DOWNLOAD

 IGG

:: MORE INFORMATION

Citation

Li et al. (2009)
IGG3: a tool to rapidly integrate large genotype datasets for whole-genome imputation and individual-level meta-analysis.
Bioinformatics 25(11):1449-50.

MaCH-Admix 2.0.203 – Genotype Imputation for Admixed Populations or with Large Reference Panels

MaCH-Admix 2.0.203

:: DESCRIPTION

MaCH-Admix is a genotype imputation software that extends the capabilities of MaCH. It has incorporated a novel piecewise reference selection method to create reference panels tailored for target individual(s).

::DEVELOPER

Yun Li Statistical Genetics Group

:: SCREENSHOTS

N/A

::REQUIREMENTS

  • Linux/ Windows/MacOsX

:: DOWNLOAD

 MaCH-Admix

:: MORE INFORMATION

Citation

MaCH-admix: genotype imputation for admixed populations.
Liu EY, Li M, Wang W, Li Y.
Genet Epidemiol. 2013 Jan;37(1):25-37. doi: 10.1002/gepi.21690. Epub 2012 Oct 16.

Geno2pheno 3.4 – Estimating Phenotypic Drug Resistance from HIV-1 Genotypes

Geno2pheno 3.4

:: DESCRIPTION

Geno2pheno is a web server for the prediction of HIV phenotypic drug resistance and coreceptor usage from genotype.

::DEVELOPER

the Computational Biology Group (CBG)

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

Geno2pheno: Estimating phenotypic drug resistance from HIV-1 genotypes.
Beerenwinkel N, Däumer M, Oette M, Korn K, Hoffmann D, Kaiser R, Lengauer T, Selbig J, Walter H.
Nucleic Acids Res. 2003 Jul 1;31(13):3850-5.

MarViN 0.1.0 – Rapid Genotype Refinement for Whole-Genome Sequencing Data using Multi-Variate Normal Distribution

MarViN 0.1.0

:: DESCRIPTION

MarViN is an algorithm that models  linkage-disequilibrium (LD) using a simple multivariate Gaussian distribution.

::DEVELOPER

Illumina

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 MarViN

:: MORE INFORMATION

Citation:

Rapid genotype refinement for whole-genome sequencing data using multi-variate normal distributions.
Arthur R, O’Connell J, Schulz-Trieglaff O, Cox AJ.
Bioinformatics. 2016 Mar 9. pii: btw097

Genonets – Analysis and Visualization of Genotype Networks

Genonets

:: DESCRIPTION

Genonets Server is a tool that provides the following features: (i) the construction of genotype networks for categorical and univariate phenotypes from DNA, RNA, amino acid or binary sequences; (ii) analyses of genotype network topology and how it relates to robustness and evolvability, as well as analyses of genotype network topography and how it relates to the navigability of a genotype network via mutation and natural selection; (iii) multiple interactive visualizations that facilitate exploratory research and education.

::DEVELOPER

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Web browser

:: DOWNLOAD

 NO

:: MORE INFORMATION

Citation

Genonets server-a web server for the construction, analysis and visualization of genotype networks.
Khalid F, Aguilar-Rodríguez J, Wagner A, Payne JL.
Nucleic Acids Res. 2016 Apr 22. pii: gkw313.