DIVERGE is designed to detect functional divergence between member genes of a protein family, based on (site-specific) shifted evolutionary rates after gene duplication or speciation. Posterior analysis results in a site-specific profile for predicting important amino acid residues that are responsible for functional divergence. Moreover, when the 3D protein structure is available, these predicted sites can be mapped to the 3D structure viewer to explore its structure basis.
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Gu, X. (1999)
Statistical methods for testing functional divergence after gene duplication.
Molecular Biology and Evolution 16:1664-1674.