The R package icbn implements algorithms for parameter estimation and model selection for Isotonic Conjunctive Bayesian Network (I-CBN) models. I-CBNs combine isotonic regression on a partially ordered set with CBNs for estimating order constraints among events. The model has been developed to jointly estimate mutational order constraints among genetic events and a genotype-phenotype mapping (such as a fitness landscape) that is non-decreasing along the lattice of genotypes.
- Windows / Linux / MacOsX
- R package
:: MORE INFORMATION
Beerenwinkel N, Knupfer P, Tresch A (2011).
Learning monotonic genotype-phenotype maps.
Stat Appl Genet Mol Biol, Vol. 10, Iss. 1, Art. 3.