The BPDA2d software package can be used for peptide detection in LC-MS data with resolution high enough to baseline-resolve isotopic peaks. BPDA2d achieves peptide deisotoping and charge state deconvolution simultaneously. It systematically evaluates all possible combinations of possible peptide candidates for spectra interpretation, and optimizes peptide signals in order to minimize the mean squared error between inferred and observed spectra.
- Linux / Windows/ MacOsX
:: MORE INFORMATION
Bioinformatics. 2012 Feb 15;28(4):564-72. doi: 10.1093/bioinformatics/btr675. Epub 2011 Dec 6.
BPDA2d–a 2D global optimization-based Bayesian peptide detection algorithm for liquid chromatograph-mass spectrometry.
Sun Y1, Zhang J, Braga-Neto U, Dougherty ER.