SPRING is a template-base algorithm for protein-protein structure prediction. It first threads one chain of the protein complex through the PDB library with the binding parters retrieved from the original oligomer entries. The complex models associated with another chain is deduced from a pre-calculated look-up table, with the best orientation selected by the SPRING-score which is a combination of threading Z-score, interface contacts, and TM-align match between monomer-to-dimer templates.
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J Chem Inf Model. 2013 Mar 25;53(3):717-25. doi: 10.1021/ci300579r. Epub 2013 Feb 27.
Mapping monomeric threading to protein-protein structure prediction.
Guerler A1, Govindarajoo B, Zhang Y.