SpotOn is a robust algorithm developed to identify and classify the interfacial residues as Hot-Spots (HS) and Null-Spots (NS) with a final accuracy of 0.95 and a sensitivity of 0.95 on an independent test set.
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SpotOn: High Accuracy Identification of Protein-Protein Interface Hot-Spots.
Moreira IS, et al.
Sci Rep, 7 (1), 8007 2017 Aug 14