Spotlite is a user-friendly web application for predicting complex co-membership from affinity purification – mass spectrometry data. This web application employs a logistic regression classifier that integrates existing, proven APMS scoring approaches (SAINT, CompPASS, and HGSCore), gene co-expression patterns, functional annotations, domain-domain binding affinity, and homologous interactions, which we have shown outperforms existing APMS scoring methods.
- Web Browser
:: MORE INFORMATION
J Proteome Res. 2014 Dec 5;13(12):5944-55. doi: 10.1021/pr5008416. Epub 2014 Oct 20.
Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification–mass spectrometry data.
Goldfarb D1, Hast BE, Wang W, Major MB.