SPEED is a signaling pathway annotation enrichment analysis tool with annotations based on evidences from pathway perturbation experiments. Thus, genes are annotated based on causal influences of pathway perturbations as opposed to pathway memberships alone. Identifying modulated pathways upstream of differentially expressed genes can facilitate the understanding of involved regulatory mechanisms. Currently only human genes and pathways are supported.
Computational Biology Laboratory – Boston University
- Linux / Windows / MacOsX
:: MORE INFORMATION
Parikh JR, Klinger B, Xia Y, Marto JA, Blüthgen N.
Discovering causal signaling pathways through gene-expression patterns.
Nucleic Acids Res. 2010 Jul 1;38 Suppl:W109-17.