SPEDRE is a method for estimating rate constants in a biochemical signaling network, and it is tailored for a special class of data-rich problems with observations of all species — problems that occur mainly when using proteomics technologies such as SILAC.
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Nucleic Acids Res. 2013 Jul;41(Web Server issue):W187-91. doi: 10.1093/nar/gkt459.
SPEDRE: a web server for estimating rate parameters for cell signaling dynamics in data-rich environments.
Nim TH, White JK, Tucker-Kellogg L.