Successful integration of computer simulation with wet-lab research requires the relationship between simulation and the real-world system to be established. Spartan (Simulation Parameter Analysis RToolkit ApplicatioN) is a package of statistical techniques specifically designed to help researchers understand this relationship and provide novel biological insight.
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PLoS Comput Biol. 2013;9(2):e1002916. doi: 10.1371/journal.pcbi.1002916. Epub 2013 Feb 28.
Spartan: a comprehensive tool for understanding uncertainty in simulations of biological systems.
Alden K1, Read M, Timmis J, Andrews PS, Veiga-Fernandes H, Coles M.