Socrates is a highly efficient and effective method for detecting genomic rearrangements in tumours that utilises split-read data. Socrates features single nucleotide resolution, high sensitivity, and high specificity in simulated data.
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Bioinformatics. 2014 Jan 22. [Epub ahead of print]
Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads.
Schröder J1, Hsu A, Boyle SE, Macintyre G, Cmero M, Tothill RW, Johnstone RW, Shackleton M, Papenfuss AT.