SNPHarvester detects SNP–SNP interactions in GWA studies. SNPHarvester creates multiple paths in which the visited SNP groups tend to be statistically associated with diseases, and then harvests those significant SNP groups which pass the statistical tests. It greatly reduces the number of SNPs. Consequently, existing tools can be directly used to detect epistatic interactions.
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SNPHarvester: a filtering-based approach for detecting epistatic interactions in genome-wide association studies
Can Yang, Zengyou He, Xiang Wan, Qiang Yang, Hong Xue and Weichuan Yu
Bioinformatics (2009) 25 (4): 504-511.