SNPfold evaluates the effects of SNPs (Single Nucleotide Polymorphisms) on the ensemble structure of an RNA. It takes as input an RNA sequence and one or more SNPs, and then evaluates the structural consequences of the mutation by computing a WT/SNP correlation coefficient. The smaller the correlation the larger the structural effects of the SNP.
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PLoS Genet. 2010 Aug 19;6(8):e1001074. doi: 10.1371/journal.pgen.1001074.
Disease-associated mutations that alter the RNA structural ensemble.
Halvorsen M, Martin JS, Broadaway S, Laederach A.