Sep 022013
 

SMETHILLIUM 1.2

:: DESCRIPTION

SMETHILLIUM is a  spatial normalisation method for ILLumina InfinIUM HumanMethylation BeadChip. DNA methylation is a major epigenetic modification in human cells. Illumina HumanMethylation27 BeadChip investigates the methylation of 27,578 loci in the genome. We developed a normalisation method to correct the spatial background noise which affect the signal-to-noise ratio. The prediction performance of the proposed method was assessed on methylated and unmethylated samples. We demonstrate that the spatial normalisation outperforms BeadStudio to predict the methylation status of a given locus

::DEVELOPER

Computational Systems Biology of Cancer group in Bioinformatics Laboratory of Institut Curie (Paris).

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

  SMETHILLIUM

:: MORE INFORMATION

Citation:

Bioinformatics. 2011 Jun 15;27(12):1693-5. Epub 2011 Apr 14.
SMETHILLIUM: spatial normalization method for Illumina infinium HumanMethylation BeadChip.
Sabbah C, Mazo G, Paccard C, Reyal F, Hupé P.

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