SMETHILLIUM is a spatial normalisation method for ILLumina InfinIUM HumanMethylation BeadChip. DNA methylation is a major epigenetic modification in human cells. Illumina HumanMethylation27 BeadChip investigates the methylation of 27,578 loci in the genome. We developed a normalisation method to correct the spatial background noise which affect the signal-to-noise ratio. The prediction performance of the proposed method was assessed on methylated and unmethylated samples. We demonstrate that the spatial normalisation outperforms BeadStudio to predict the methylation status of a given locus
:: MORE INFORMATION
Bioinformatics. 2011 Jun 15;27(12):1693-5. Epub 2011 Apr 14.
SMETHILLIUM: spatial normalization method for Illumina infinium HumanMethylation BeadChip.
Sabbah C, Mazo G, Paccard C, Reyal F, Hupé P.