The program SLINK is a general computer simulation program that employs a variation of the algorithm described by Ott (1989). Suppose there are N people in a pedigree. Let x = (x1,x2,…,xN) represent the vector of phenotypes of the N people in the pedigree. Likewise, let g = (g1, g2,…,gN) represent the vector of multi-locus genotypes including phase information.
Division of Statistical Genetics
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Hum Hered. 2011;71(2):126-34. doi: 10.1159/000324177. Epub 2011 Jul 6.
Coordinated conditional simulation with SLINK and SUP of many markers linked or associated to a trait in large pedigrees.
Schäffer AA1, Lemire M, Ott J, Lathrop GM, Weeks DE.
Weeks DE, Ott J, Lathrop GM (1990)
SLINK: a general simulation program for linkage analysis.
Am J Hum Genet 47:A204