Sim4 is a similarity-based tool for aligning an expressed DNA sequence (EST, cDNA, mRNA) with a genomic sequence for the gene. It also detects end matches when the two input sequences overlap at one end (i.e., the start of one sequence overlaps the end of the other).
Webb Miller’s lab at the Pennsylvania State University.
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Liliana Florea, George Hartzell, Zheng Zhang, Gerald M. Rubin, and Webb Miller
A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence
Genome Res. 1998. 8: 967-974