Apr 022014
 

SIM

:: DESCRIPTION

SIM is a software of cell- and gene-based computer model for mammalian somitogenesis, simulating a gene regulatory network combining clock (Hes1/7) and gradient (Tbx6, Fgf8, Wnt3a) with Delta/Notch signaling resulting in dynamic gene expression patterns as observed in vivo finally leading to boundary formation.

::DEVELOPER

Institute of Experimental Genetics , German Research Center for Environmental Health (GmbH)

:: SCREENSHOTS

SIM

:: REQUIREMENTS

  • Windows / Linux / MacOsX
  • Java 

:: DOWNLOAD

 SIM

:: MORE INFORMATION

Citation

Tiedemann HB, Schneltzer E, Zeiser S, Hoesel B, Beckers J, Przemeck GKH, Hrabě de Angelis M. (2012).
From dynamic Expression patterns to Boundary Formation in the Presomitic mesoderm
PLoS Comput Biol 8(6): e1002586. doi:10.1371/journal.pcbi.1002586

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