Jan 282015
 

SiGN-SSM 1.2.1 / SiGN-L1 1.0.0

:: DESCRIPTION

SiGN-SSM  is open source gene network estimation software able to run in parallel on PCs and massively parallel supercomputers. The software estimates a state space model (SSM), that is a statistical dynamic model suitable for analyzing short time and/or replicated time series gene expression profiles. SiGN-SSM implements a novel parameter constraint effective to stabilize the estimated models. Also, by using a supercomputer, it is able to determine the gene network structure by the statistical permutation test in a practical time. SiGN-SSM is applicable not only to analyzing temporal regulatory dependencies between genes, but also to extracting the differentially regulated genes from time series expression profiles.

SiGN-L1 is network estimation software using sparse learning. It uses L1-regularization for simultaneous parameter estimation and model selection of statistical graphical models such as graphical Gaussian models and vector autoregressive models.

::DEVELOPER

SiGN-SSM TEam

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows / Linux / Mac OsX

:: DOWNLOAD

 SiGN-SSM , SiGN-L1

:: MORE INFORMATION

Citation

Tamada, Y., Yamaguchi, R., Imoto, S., Hirose, O., Yoshida, R., Nagasaki, M., and Miyano, S. (2011).
SiGN-SSM: open source parallel software for estimating gene networks with state space models.
Bioinformatics. 2011 Apr 15;27(8):1172-3. doi: 10.1093/bioinformatics/btr078.

Genome Inform. 2011;25(1):40-52.
Sign: large-scale gene network estimation environment for high performance computing.
Tamada Y, Shimamura T, Yamaguchi R, Imoto S, Nagasaki M, Miyano S.

221 views

Sorry, the comment form is closed at this time.