SIFT (Sorting Intolerant From Tolerant) is a program for predicting whether an amino acid substitution affects protein function, based on sequence homology and the physical properties of amino acids. It is one of several programs using sequence information for this purpose.
:: MORE INFORMATION
Ng PC, Henikoff S. 2002.
Accounting for human polymorphisms predicted to affect protein function.
Genome Research 12:436-446. doi:10.1101/gr.212802