SIBLINK allows the user to perform multipoint linkage analysis based on estimated IBD sharing between affected sibpairs. IBD sharing is inferred from IBS status, given marker genotypes, frequencies, and locations. Resulting LOD scores are maximized across a grid of possible disease locations and IBD sharing vectors.
- Solaris 7 (or higher)
:: MORE INFORMATION
Shah SH, Schmidt MA, Mei H, Scott WK, Hauser ER, Schmidt S.
Searching for epistatic interactions in nuclear families using conditional linkage analysis.
BMC Genet. 2005 Dec 30;6 Suppl 1:S148.