SHREC is a new algorithm for correcting errors in short-read data that uses a generalized suffix trie on the read data as the underlying data structure. Our results show that the method can identify erroneous reads with sensitivity and specificity of over 99% and 96% for simulated data with error rates of up to 3% as well as for real data. Furthermore, it achieves an error correction accuracy of over 80% for simulated data and over 88% for real data. These results are clearly superior to previously published approaches.
:: MORE INFORMATION
Jan Schröder, Heiko Schröder, Simon J. Puglisi, Ranjan Sinha, and Bertil Schmidt,
SHREC: A short-read error correction method,
Bioinformatics, 2009 25(17):2157-2163.