Sherlocc is a PERL written program able to scan Pfam protein families for conserved regions that have a low codon usage frequency (rare codon clusters). This program represents a novel approach as it is efficient enough to perform large-scale analysis of the proteome via the Pfam protein family database (representing about 70% of the known protein universe).
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Bioinformatics. 2012 Jun 1;28(11):1438-45. doi: 10.1093/bioinformatics/bts149. Epub 2012 Mar 30.
Large-scale analysis of conserved rare codon clusters suggests an involvement in co-translational molecular recognition events.
Chartier M, Gaudreault F, Najmanovich R.