SEPPA (Spatial Epitope Prediction of Protein Antigens) is presented here as an updated server for conformational B-cell epitope prediction. With PDB structure as input, each residue in the query protein will be given a score according to not only its physical-chemical properties and neighborhood residues’ information but also its subcellular localization and species of immune host. Higher score corresponds to higher probability of the residue to be become an epitope residue.
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SEPPA 2.0-more refined server to predict spatial epitope considering species of immune host and subcellular localization of protein antigen.
Qi T, Qiu T, Zhang Q, Tang K, Fan Y, Qiu J, Wu D, Zhang W, Chen Y, Gao J, Zhu R, Cao Z.
Nucleic Acids Res. 2014 May 16. pii: gku395