SEMPPR is a model of a protein’s production rate. SEMPPR assumes that the evolution of codon bias is driven by selection to reduce the cost of nonsense errors and that this selection is counteracted by mutation and drift. Through the application of Bayes’ theorem, SEMPPR generates a posterior probability distribution for the protein production rate of a given gene.
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Gilchrist, M. A. (2007)
Combining Models of Protein Translation and Population Genetics to Predict Protein Production Rates from Codon Usage Patterns.
Mol Biol Evol (2007) 24 (11): 2362-2372.