The Selecton server enables detecting the selective forces at a single amino-acid site. The ratio of non-synonymous (amino-acid altering) to synonymous (silent) substitutions, known as the Ka/Ks ratio, is used to estimate both positive and purifying selection at each amino-acid site.
- Linux / Windows /MacOsX
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Stern, A., Doron-Faigenboim, A., Erez, E., Martz, E., Bacharach, E., Pupko, T.
Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach.
Nucleic Acids Research. 35: W506-W511.