SEAS is a computational tool for pathway enrichment analysis over a given set of genes in a specified organism against pathways (or subsystems) in the SEED database, a popular pathway database for bacteria. SEAS maps a given set of genes in a bacterium to genes currently covered by SEED through gene ID and/or orthology mapping, and then calculates the statistical significance of the enrichment of each relevant SEED pathway by the mapped genes.
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PLoS One. 2011;6(7):e22556. Epub 2011 Jul 22.
SEAS: a system for SEED-based pathway enrichment analysis.
Mao X, Zhang Y, Xu Y.