SCooP is a fast and accurate method for predicting the Gibbs-Helmholtz equation associated to the folding transition of a target protein of known (or modeled) structure. In addition, SCooP yields an estimation of the thermodynamic quantities that characterize the folding process, in particular the change in enthalpy and in heat capacity upon folding, the melting temperature and the folding free energy at room temperature.
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F. Pucci, J.M. Kwasigroch, M. Rooman (2017),
SCooP : an accurate and fast predictor of protein stability curves as a function of the temperature,
Bioinformatics 33, 3415-3422.