SciClone is an R package for inferring the subclonal architecture of tumors.It is the first method that can efficiently detect subclonal populations of neoplastic cells by leveraging somatic mutation data from many samples of a tumor. This capability allows it to detect “cryptic” subclones that cannot be identified from a single primary tumor.
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Christopher A. Miller et al.
SciClone: Inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.