SBSPKS is a webserver for carrying out sequence and structure based analysis of Polyketide Synthases, an important family of multifunctional megasynthases involved in the biosynthesis of a variety of pharmaceutically important secondary metabolites. The knowledge base for development of SBSPKS is derived from a comprehensive bioinformatics analysis of the sequence and structural features of a large number of experimentally characterized PKS gene clusters having known metabolic products and recently available crystal structures of PKS and FAS proteins.The interfaces for carrying out various tasks by SBSPKS are organized as three major functional units, namely NRPS_PKS, Model_3D_PKS and Dock_Dom_Anal .
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Nucleic Acids Res. 2010 Jul;38(Web Server issue):W487-96. Epub 2010 May 5.
SBSPKS: structure based sequence analysis of polyketide synthases.
Anand S, Prasad MV, Yadav G, Kumar N, Shehara J, Ansari MZ, Mohanty D.