Applying the LIBSVM, a package of support vector machine, SAMSVM was developed to correctly detect and filter the misaligned reads of SAM format. Such filtration can reduce false positives in alignment and the following variant analysis.
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SAMSVM: A tool for misalignment filtration of SAM-format sequences with support vector machine.
Yang J, Ding X, Sun X, Tsang SY, Xue H.
J Bioinform Comput Biol. 2015 Aug 24:1550025.